Fuzhuan Tea protects Caenorhabditis elegans from glucose and advanced glycation end products via distinct pathways
Autor: | Yushun Gong, Li-Gui Xiong, Jianan Huang, Zhonghua Liu, Lian-Yun Pan |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
MAPK/ERK pathway Normal diet p38 mitogen-activated protein kinases medicine.medical_treatment Medicine (miscellaneous) Fuzhuan Tea Biology medicine.disease_cause AGEs 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Glycation medicine TX341-641 030109 nutrition & dietetics Nutrition and Dietetics Lifespan Nutrition. Foods and food supply Insulin Fructose 04 agricultural and veterinary sciences 040401 food science Cell biology Glucose chemistry Toxicity C. elegans Oxidative stress Food Science |
Zdroj: | Journal of Functional Foods, Vol 59, Iss, Pp 148-155 (2019) |
ISSN: | 1756-4646 |
Popis: | Fuzhuan Tea (FZT) protects against obesity and obesity-related disorders. However, little is known about its effects on high-sugar toxicity in Caenorhabditis elegans. Here, we find that FZT limits the life-shortening effects of a high-sugar (glucose, sucrose, galactose, and fructose) diet, but does not extend lifespan on a normal diet or protect against oxidative stress. FZT also can prolong healthspan and alleviate the detrimental effects of a glucose-rich diet. Furthermore, we report that effects of FZT on glucose toxicity and advanced glycation end products (AGEs) damage can be dissociated. Notably, FZT is dependent on DAF-16/FOXO and the insulin/IGF-1 signaling (IIS) pathway to promote lifespan and decrease fat content on a glucose-rich diet; concomitantly, FZT reduces AGEs levels by regulating SKN-1/Nrf and p38/mitogen-activated protein kinase (MAPK) pathway, independent of DAF-16/FOXO and IIS pathway. Our findings indicate that FZT protects against high glucose toxicity by a mechanism other than protection against AGEs damage. |
Databáze: | OpenAIRE |
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