Targeting protein–protein interactions, a wide open field for drug design
| Autor: | May Bakail, Françoise Ochsenbein |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Petite molécule Chemistry(all) Peptidomimetic Computer science General Chemical Engineering Nanotechnology Computational biology Drug design Protein–protein interaction Interaction protéine–protéine 03 medical and health sciences Peptidomimétiques Antibody Anticorps Structure General Chemistry Small molecule 030104 developmental biology Peptide Chemical Engineering(all) Design de médicaments Strengths and weaknesses |
| Zdroj: | Comptes Rendus Chimie. 19(1-2):19-27 |
| ISSN: | 1631-0748 |
| DOI: | 10.1016/j.crci.2015.12.004 |
| Popis: | Targeting protein–protein interactions has long been considered as a very difficult if impossible task, but over the past decade, front lines have moved. The number of successful examples is exponentially growing. This review presents a rapid overview of recent advances in this field considering the strengths and weaknesses of the small molecule approaches and alternative strategies such as the selection or design of artificial antibodies, peptides or peptidomimetics. |
| Databáze: | OpenAIRE |
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