Toxicological effects in rats chronically fed low dietary levels of fumonisin B(1)
| Autor: | Sonja Swanevelder, Wentzel C. A. Gelderblom, W. F. O. Marasas, Petra W. Snijman, Stefan Abel, S. Lebepe-Mazur, N.P.J. Kriek |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Necrosis Carboxylic Acids Biology Toxicology Kidney Fumonisins Thiobarbituric Acid Reactive Substances chemistry.chemical_compound Oral administration Fibrosis Internal medicine medicine Animals Fumonisin B1 Dose-Response Relationship Drug Bile duct Body Weight Organ Size medicine.disease Diet Rats medicine.anatomical_structure Endocrinology Cholesterol Teratogens chemistry Liver Hepatocyte Toxicity medicine.symptom |
| Zdroj: | Toxicology. 161(1-2) |
| ISSN: | 0300-483X |
| Popis: | The toxicity of low dietary levels of fumonisin B1 (FB1), i.e. 1, 10 and 25 mg FB1:kg diet, were monitored in rats over a period of 24 months. No effects on the body weight gain and feed intake profiles were noticed, while the relative liver weight was significantly (PB0.05) reduced in the FB1-treated rats. Mild toxic effects, including single cell necrosis (apoptosis), proliferation of bile duct epithelial cells (DEC), and early signs of fibrosis, bile duct hyperplasia and in one case, adenofibrosis, were noticed in the liver of the rats fed the highest (25 mg:FB1:kg diet) dietary level. A significant (PB0.05) increase in the level of oxidative damage was also noticed in the liver of the rats of high dosage dietary group. The toxic effects were less severe in the 10 mg FB1:kg dietary group, whilst only a few ground glass foci were observed in the 1 mg FB1:kg dietary group. Hepatocyte nodules, staining positively for glutathione-S-transferase (placental form, PGST), were observed macroscopically in the 25 mg FB1:kg treated group and to a lesser extent in the 10 mg FB1:kg treated rats. The most prominent toxic lesions by FB1 (10 and 25 mg FB1:kg dietary groups) in the kidneys were restricted to the tubular epithelium manifesting as granular cast, necrosis, apoptosis, calcification and the presence of regenerative foci in the proximal convoluted tubules. The existence of a cytotoxic:proliferative threshold with respect to cancer induction by FB1 in rat liver became apparent, with a dietary level of B10-mg FB1:kg diet as a no effect threshold for the induction of hepatocyte nodules. © 2001 Elsevier Science Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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