Chloracne associated with employment in the production of pentachlorophenol
| Autor: | William E. Halperin, Arvind V. Carpenter, David Marlow, C. G. Mathias, Marilyn A. Fingerhut, Marie Haring Sweeney, Michael A. O'Malley |
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| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Pentachlorophenol Occupational disease Dermatitis Contact Annual incidence chemistry.chemical_compound Risk Factors Acne Vulgaris medicine Humans Cumulative incidence business.industry Incidence Public Health Environmental and Occupational Health medicine.disease Dermatology Confidence interval Chloracne Increased risk Cross-Sectional Studies chemistry Dermatitis Occupational Chemical Industry Illinois Risk assessment business Chlorophenols |
| Zdroj: | American journal of industrial medicine. 17(4) |
| ISSN: | 0271-3586 |
| Popis: | To evaluate the association between exposure to pentachlorophenol (PCP) and the occurrence of chloracne, we studied the medical and personnel records for individuals employed in the manufacturing of PCP. Forty-seven cases of chloracne were identified among 648 workers (7.0%) assigned to PCP production at a single plant between 1953 and 1978. The annual incidence rate varied considerably, ranging from 0 (in 1953) to 1.46 (in 1978). No linear trend in the risk of chloracne was observed with the duration of employment in the pentachlorophenol department. Workers with a documented episode of direct skin contact with PCP had a significantly increased risk of chloracne compared with workers who did not have a documented episode of direct skin contact (cumulative incidence ratio = 4.6; 95% confidence interval 2.6-8.1). Our results confirm that chloracne is associated with exposure to PCP contaminated with hexachlorinated, heptachlorinated, and octachlorinated dibenzo-p-dioxins and dibenzofurans. |
| Databáze: | OpenAIRE |
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