Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients

Autor:	Serhan Ünlü, Junghee Jenny Shin, Jennefer Par-Young, Michael Simonov, Joseph Vinetz, Daniel P. Petrylak, Insoo Kang, Joseph W. Kim
Rok vydání:	2022
Předmět:	Cancer Research Oncology General Medicine
Zdroj:	Cancer Investigation. 41:77-83
ISSN:	1532-4192 0735-7907
DOI:	10.1080/07357907.2022.2139839
Popis:	TMPRSS2 is utilized by SARS-CoV-2 for cellular entry. Androgen-Androgen receptor directed therapy (A/ARDT) downregulates expression of TMPRSS2. We hypothesized A/ARDT might protect prostate cancer (PCa) patients from poor COVID-19 outcome. A retrospective analysis of PCa patients with COVID-19 infection was performed. 146 PCa cases were identified, 17% were on A/ARDT. Hospitalization rates were same 52% (OR = 0.99, 0.41-2.24). Mean hospitalization was 9.2 (Range: 1-25) and 14.9 (Range: 2-47) days in A/ARDT and non-A/ARDT groups, respectively. While definitive conclusions cannot be made regarding outcome differences between groups due to lack of statistical significance, these data generate hypothesis that A/ARDT might shorten hospitalization stay.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c124e8f3f31df7d6372acea2425403b3 https://doi.org/10.1080/07357907.2022.2139839 Zobrazit plný text záznamu