Evaluation of dental maturity in Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis
| Autor: | Irene Margreet Jacqueline Mathijssen, Tsun Man Choi, Jacqueline A C Goos, Edwin M. Ongkosuwito, Gem J. C. Kramer, Eppo B. Wolvius |
|---|---|
| Přispěvatelé: | Orthodontics, Oral and Maxillofacial Surgery, Plastic and Reconstructive Surgery and Hand Surgery |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Pediatrics
medicine.medical_specialty business.industry Orthodontics Syndrome Acrocephalosyndactylia Dental age medicine.disease Dental care Muenke syndrome Craniosynostosis Craniosynostoses Child Preschool Basic Helix-Loop-Helix Transcription Factors medicine Humans In patient University medical Saethre–Chotzen syndrome Child business Dental maturity Netherlands |
| Zdroj: | Choi, T M, Kramer, G J C, Goos, J A C, Mathijssen, I M J, Wolvius, E B & Ongkosuwito, E M 2022, ' Evaluation of dental maturity in Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis ', European Journal of Orthodontics, vol. 44, no. 3, pp. 287-293 . https://doi.org/10.1093/ejo/cjab056 European Journal of Orthodontics, 44(3), 287-293. Oxford University Press |
| ISSN: | 0141-5387 |
| Popis: | Objectives To determine whether dental maturity (dental development) was delayed in patients with Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis, compared with a Dutch control group without syndromes. Materials and methods This study included 60 patients (38 patients with Muenke syndrome, 17 patients with Saethre-Chotzen syndrome, and 5 with TCF12-related craniosynostosis), aged 5.8–16.8 years that were treated at the Department of Oral Maxillofacial Surgery, Special Dental Care, and Orthodontics, in Sophia Children’s Hospital, Erasmus University Medical Center, Rotterdam, the Netherlands. Dental age was calculated according to Demirjian’s index of dental maturity. The control group included 451 children without a syndrome. Results Compared with the control group, dental development was delayed by an average of one year in 5- to 8-year-old patients with Muenke syndrome (P = 0.007) and in 8- to 10-year-old patients with Saethre-Chotzen syndrome (P = 0.044), but not in patients with TCF12-related craniosynostosis. Conclusions Our results indicated that dental development was delayed by one year, on average, in patients with Muenke syndrome and Saethre-Chotzen syndrome, compared with a Dutch control group without syndromes. Implications Our findings have improved the understanding of dental development in patients with Muenke and Saethre-Chotzen syndrome. These results can provide guidance on whether the orthodontist needs to consider growth disturbances related to dental development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|