Biocompatibility study on Ni-free Ti-based and Zr-based bulk metallic glasses
| Autor: | T.H. Li, J.S.C. Jang, P.H. Tsai, S.F. Chang, J.C. Huang, Pei Chun Wong |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Biocompatibility chemistry.chemical_element Bioengineering 02 engineering and technology 01 natural sciences Corrosion Cell Line Biomaterials Metal Mice Nickel 0103 physical sciences Materials Testing Cell Adhesion Animals Composite material 010302 applied physics Titanium Zirconium Amorphous metal Titanium alloy Adhesion Fibroblasts 021001 nanoscience & nanotechnology chemistry Mechanics of Materials visual_art visual_art.visual_art_medium Glass 0210 nano-technology |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 75 |
| ISSN: | 1873-0191 |
| Popis: | Safety and reliability are crucial issues for medical instruments and implants. In the past few decays, bulk metallic glasses (BMGs) have drawn attentions due to their superior mechanical properties, good corrosion resistance, antibacterial and good biocompatibility. However, most Zr-based and Ti-based BMGs contain Ni as an important element which is prone to human allergy problem. In this study, the Ni-free Ti-based and Zr-based BMGs, Ti40Zr10Cu36Pd14, and Zr48Cu36Al8Ag8, were selected for systematical evaluation of their biocompatibility. Several biocompatibility tests, co-cultural with L929 murine fibroblast cell line, were carried out on these two BMGs, as well as the comparison samples of Ti6Al4V and pure Cu. The results in terms of cellular adhesion, cytotoxicity, and metallic ion release affection reveal that the Ti40Zr10Cu36Pd14 BMG and Ti6Al4V exhibit the optimum biocompatibility; cells still being attached on the petri dish with good adhesion and exhibiting the spindle shape after direct contact test. Furthermore, the Ti40Zr10Cu36Pd14 BMG showed very low Cu ion release level, in agreement with the MTT results. Based on the current findings, it is believed that Ni-free Ti-based BMG can act as an ideal candidate for medical implant. |
| Databáze: | OpenAIRE |
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