Physiologically based kinetic modeling of hesperidin metabolism and its use to predict in vivo effective doses in humans
| Autor: | Ivonne M.C.M. Rietjens, Rungnapa Boonpawa, A. Spenkelink, Ans Punt |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Administration Oral Pharmacology Toxicology Models Biological Nitric oxide Excretion 03 medical and health sciences chemistry.chemical_compound Hesperidin In vitro-in vivo extrapolation In vivo medicine Humans Prostaglandin E2 Hesperetin metabolites Toxicologie ADME VLAG 030109 nutrition & dietetics Dose-Response Relationship Drug Chemistry Hesperetin Metabolism Cyclic AMP-Dependent Protein Kinases Kinetics PBK modeling 030104 developmental biology Food Science Biotechnology medicine.drug |
| Zdroj: | Molecular Nutrition & Food Research, 61(8) Molecular Nutrition & Food Research 61 (2017) 8 |
| ISSN: | 1613-4125 |
| Popis: | cope To develop a physiologically based kinetic (PBK) model that describes the absorption, distribution, metabolism, and excretion of hesperidin in humans, enabling the translation of in vitro concentration–response curves to in vivo dose–response curves. Methods and results The PBK model for hesperidin in humans was developed based on in vitro metabolic parameters. Hesperidin was predicted to mainly occur in the systemic circulation as different monoglucuronides. The plasma concentrations of hesperidin aglycone (hesperetin) was predicted to be |
| Databáze: | OpenAIRE |
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