Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications
| Autor: | Rogério Leone Buchaim, Ricardo José Tofano, Sandra Maria Barbalho, Piero Biteli, Cláudia Rucco Penteado Detregiachi, Uri Adrian Prync Flato, Elen Landgraf Guiguer, Daniela Ortega Balbo Rodrigues Reina, Marcelo Dib Bechara, Daniela Vieira Buchaim, Ricardo de Alvares Goulart, Adriano Cressoni Araújo, Fábio Tadeu Rodrigues Reina |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
myokines Cardiomyopathy Physical exercise Review Cell Communication 030204 cardiovascular system & hematology Bioinformatics Catalysis Inorganic Chemistry sarcopenia lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Adipokines Myokine medicine Endocrine system Animals Humans Physical and Theoretical Chemistry Muscle Skeletal Molecular Biology Exercise lcsh:QH301-705.5 Spectroscopy business.industry Organic Chemistry Skeletal muscle General Medicine medicine.disease Computer Science Applications cardiovascular diseases DOENÇAS CARDIOVASCULARES 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 Sarcopenia Heart failure Cytokines Metabolic syndrome business |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 3607, p 3607 (2020) International Journal of Molecular Sciences Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Skeletal muscle is capable of secreting different factors in order to communicate with other tissues. These mediators, the myokines, show potentially far-reaching effects on non-muscle tissues and can provide a molecular interaction between muscle and body physiology. Sarcopenia is a chronic degenerative neuromuscular disease closely related to cardiomyopathy and chronic heart failure, which influences the production and release of myokines. Our objective was to explore the relationship between myokines, sarcopenia, and cardiovascular diseases (CVD). The autocrine, paracrine, and endocrine actions of myokines include regulation of energy expenditure, insulin sensitivity, lipolysis, free fatty acid oxidation, adipocyte browning, glycogenolysis, glycogenesis, and general metabolism. A sedentary lifestyle accelerates the aging process and is a risk factor for developing sarcopenia, metabolic syndrome, and CVD. Increased adipose tissue resulting from the decrease in muscle mass in patients with sarcopenia may also be involved in the pathology of CVD. Myokines are protagonists in the complex condition of sarcopenia, which is associated with adverse clinical outcomes in patients with CVD. The discovery of new pathways and the link between myokines and CVD remain a cornerstone toward multifaceted interventions and perhaps the minimization of the damage resulting from muscle loss induced by factors such as atherosclerosis. |
| Databáze: | OpenAIRE |
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