Metastatic low-grade endometrial stromal sarcoma of the sigmoid colon three years after hysterectomy
| Autor: | Noriko Nomura, Haruhiko Nakao, Fumitaka Akama, Hajime Isomoto, Shigeru Kohno, Yuki Asada, Chun-Yang Wen, Kan Toriyama, Ikuo Murata |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Pathology Time Factors Sarcoma Endometrial Stromal Case Report Hysterectomy Metastasis Sigmoidectomy Colon Sigmoid Medicine Humans Nuclear atypia Barium enema Gynecology Endometrial stromal sarcoma medicine.diagnostic_test business.industry Gastroenterology Sigmoid colon Sigmoidoscopy General Medicine Middle Aged medicine.disease digestive system diseases Endometrial Neoplasms medicine.anatomical_structure Colonic Neoplasms Female Sarcoma business |
| Popis: | A 49-year-old woman, who had undergone hysterectomy for low-grade endometrial stromal sarcoma (ESS) 3 years ago, presented with a 2-wk history of lower abdominal pain. Barium enema and sigmoidoscopy disclosed a polypoid submucosal tumor. Histopathologic features of biopsy specimens from the lesion were similar to those of the resected uterine ESS. Under the diagnosis of metastatic ESS of the sigmoid colon, sigmoidectomy was performed. Microscopic examination demonstrated dense proliferation of spindle cells with little nuclear atypia, which were sometimes arranged in whorled pattern around abundant arterioles. Mitotic count is below 1 in 10 high-power fields. Immunohistochemically, the neoplastic cells were strongly positive for vimentin, estrogen receptor and progesterone receptor but negative for alpha-smooth muscle actin, S-100 protein and CD34. Thus, a final diagnosis of low-grade ESS metastasis to the sigmoid colon was made. Her postoperative course was uneventful and hormonal therapy with progestational agents is entertained. |
| Databáze: | OpenAIRE |
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