SIRT1: Mechanism and Protective Effect in Diabetic Nephropathy
| Autor: | Jing Ji, Yuzhen Xu, Qian Wang, Lingxing Li, Pengyu Tao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism medicine.medical_treatment Calorie restriction 030209 endocrinology & metabolism Inflammation Disease Pharmacology Kidney Pathogenesis Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Sirtuin 1 Diabetes Mellitus medicine Animals Humans Immunology and Allergy Diabetic Nephropathies Proteinuria Podocytes business.industry Insulin NF-kappa B medicine.disease Symptomatic relief 030104 developmental biology medicine.symptom business |
| Zdroj: | Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:835-842 |
| ISSN: | 1871-5303 |
| DOI: | 10.2174/1871530320666201029143606 |
| Popis: | Diabetic nephropathy (DN) is referred to as the microvascular complication of the kidneys induced by insufficient production of insulin or an ineffective cellular response to insulin, and is the main cause of end-stage renal disease. Currently, available therapies provide only symptomatic relief and fail to improve the outcome of diabetic nephropathy. Studies on diabetic animals had shown overexpression of SIRT1 in both podocytes and renal tubular cells attenuated proteinuria and kidney injury in the animal model of DN. Sirt1 exerts renoprotective effects in DKD in part through the deacetylation of transcription factors involved in the disease pathogenesis, such as NF-кB, Smad3, FOXO and p53. The purpose of this review is to highlight the protective mechanism of SIRT1 involved in the pathogenesis of diabetic nephropathy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|