MicroRNA expression profiles in muscle-invasive bladder cancer: identification of a four-microRNA signature associated with patient survival
| Autor: | Lu-Wei Xu, Xiao-Bing Yang, Yan-Qiu Yu, Zheng Xu, Meng Zhu, You-Cai Zhao, Quanliang Dou, Yu-Zheng Ge, Ruipeng Jia, Jia-Geng Zhu, Li-Guo Geng |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Male medicine.medical_specialty Biology Internal medicine Histologic grade Cancer genome microRNA medicine Biomarkers Tumor Humans Neoplasm Invasiveness Aged Neoplasm Staging Muscle Neoplasms Bladder cancer Genitourinary system Gene Expression Profiling High mortality Muscle invasive Patient survival General Medicine Middle Aged medicine.disease Prognosis Carcinoma Papillary Gene Expression Regulation Neoplastic Survival Rate MicroRNAs Urinary Bladder Neoplasms Disease Progression Female Neoplasm Grading Follow-Up Studies |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 36(10) |
| ISSN: | 1423-0380 |
| Popis: | Bladder cancer ranks the second most common genitourinary tract cancer, and muscle-invasive bladder cancer (MIBC) accounts for approximately 25 % of all bladder cancer cases with high mortality. In the current study, with a total of 202 treatment-naive primary MIBC patients identified from The Cancer Genome Atlas dataset, we comprehensively analyzed the genome-wide microRNA (miRNA) expression profiles in MIBC, with the aim to investigate the relationship of miRNA expression with the progression and prognosis of MIBC, and generate a miRNA signature of prognostic capabilities. In the progression-related miRNA profiles, a total of 47, 16, 3, and 84 miRNAs were selected for pathologic T, N, M, and histologic grade, respectively. Of the eight most important progression-related miRNAs, four (let-7c, mir-125b-1, mir-193a, and mir-99a) were significantly associated with survival of patients with MIBC. Finally, a four-miRNA signature was generated and proven as a promising prognostic parameter. In summary, this study identified the specific miRNAs associated with the progression and aggressiveness of MIBC and a four-miRNA signature as a promising prognostic parameter of MIBC. |
| Databáze: | OpenAIRE |
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