The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Patients: A Randomized Controlled Trial
| Autor: | Naohisa Kaneko, Shogo Kometani, Nobuyuki Kawate, Takashi Ikeda, Arinori Kamono, Ryo Miyazawa, Nobuo Morotomi, Rikitaro Sako, Mamoru Iida, Saki Ishimoto |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Sarcopenia Time Factors medicine.medical_treatment law.invention chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Single-Blind Method 030212 general & internal medicine Leg press Stroke Nutrition and Dietetics Rehabilitation digestive oral and skin physiology Stroke Rehabilitation Middle Aged Physical Functional Performance stroke Treatment Outcome Female Leucine lcsh:Nutrition. Foods and food supply medicine.medical_specialty Branched-chain amino acid lcsh:TX341-641 Article Drug Administration Schedule 03 medical and health sciences branched chain amino acid medicine Humans Muscle Skeletal Exercise Aged Breakfast body composition 030109 nutrition & dietetics timing of supplementation business.industry medicine.disease Confidence interval chemistry Berg Balance Scale Dietary Supplements Physical therapy business Amino Acids Branched-Chain Food Science |
| Zdroj: | Nutrients Volume 12 Issue 7 Nutrients, Vol 12, Iss 1928, p 1928 (2020) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12071928 |
| Popis: | The combination of exercise and nutritional intervention is widely used for stroke patients, as well as frail or sarcopenic older persons. As previously shown, supplemental branched chain amino acids (BCAAs) or protein to gain muscle mass has usually been given just after exercise. This study investigated the effect of the timing of supplemental BCAAs with exercise intervention on physical function in stroke patients. The participants were randomly assigned to two groups based on the timing of supplementation: breakfast (n = 23) and post-exercise (n = 23). The supplement in the breakfast group was provided at 08:00 with breakfast, and in the post-exercise group it was provided just after the exercise session in the afternoon at 14:00&ndash 18:00. In both groups, the exercise intervention was performed with two sessions a day for two months. The main effects were observed in body fat mass (p = 0.02, confidence interval (CI): 13.2&ndash 17.7), leg press strength (p = 0.04, CI: 94.5&ndash 124.5), and Berg balance scale (p = 0.03, CI: 41.6&ndash 52.6), but no interaction with intake timing was observed. Although the effect of the timing of supplementation on skeletal muscle mass was similar in both groups, BCAA intake with breakfast was effective for improving physical performance and decreasing body fat mass. The results suggest that a combination of BCAA intake with breakfast and an exercise program was effective for promoting rehabilitation of post-stroke patients. |
| Databáze: | OpenAIRE |
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