Copper-Promoted C-Se Cross-Coupling of 2-Selenohydantoins with Arylboronic Acids in an Open Flask
| Autor: | Oleksandr Vyhivskyi, Egor A. Dlin, Nikolay V. Zyk, A. V. Finko, Yan A. Ivanenkov, Andrei V. Mironov, Saiyyna P. Stepanova, Elena K. Beloglazkina, Alexander G. Majouga, Dmitry A. Skvortsov |
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| Rok vydání: | 2019 |
| Předmět: |
010405 organic chemistry
Cell Survival Aryl Hydantoins chemistry.chemical_element Antineoplastic Agents General Chemistry General Medicine 010402 general chemistry 01 natural sciences Copper Combinatorial chemistry Boronic Acids In vitro 0104 chemical sciences Coupling (electronics) chemistry.chemical_compound chemistry Cell Line Tumor Cancer cell Humans Cytotoxicity Imidazolines Selenium Compounds |
| Zdroj: | ACS combinatorial science. 21(6) |
| ISSN: | 2156-8944 |
| Popis: | The modification of Chan–Lam–Evans cross-coupling reaction for the selective Se-arylation of 2-selenohydantoins under base-free mild conditions via aryl boronic acids is described herein. This approach was used to synthesize novel 5-arylidene-3-substituted-2-(arylselanyl)-imidazoline-4-ones with high yields. The anticancer activity of the final compounds was evaluated in vitro against different cancer cells, and thus, the possibility of 5-arylidene-3-substituted-2-(arylselanyl)-imidazoline-4-ones successful application as cytotoxic agents was demonstrated. |
| Databáze: | OpenAIRE |
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