How can the process of postnatal adaptation be changed by the presence of congenital abnormalities of lip and palate
| Autor: | Ingrid Brucknerová, Michal Dubovický, Eduard Ujházy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
cheiloschisis
Pediatrics medicine.medical_specialty Down syndrome Heart malformation Health Toxicology and Mutagenesis 030230 surgery Toxicology 03 medical and health sciences 0302 clinical medicine newborn RA1190-1270 Chromosomal Abnormality medicine Family history palatoschisis Pharmacology Fetus business.industry medicine.disease Palatoschisis Perinatal asphyxia 030220 oncology & carcinogenesis Toxicology. Poisons Original Article Abnormality business |
| Zdroj: | Interdisciplinary Toxicology, Vol 10, Iss 4, Pp 168-171 (2017) Interdisciplinary Toxicology |
| ISSN: | 1337-9569 |
| Popis: | Despite modern approaches in molecular biology and genetics, we are still not able to identify the actual cause in more than 50% of all congenital defects. One-half of the unidentified cases is referred to as “multifactorial”. Detailed prenatal investigation of the fetus can discover the presence of congenital abnormality, which can worsen the process of postnatal adaptation. Retrospective analysis of newborns admitted to the Neonatal Department of Intensive Medicine (NDIM) in 2012-2016 with the aim to analyze how the process of postnatal adaptation can be changed by the presence of congenital abnormalities of lip and palate. During a five-year period, 13 newborns were admitted to NDIM (2 premature; 11 term newborns). Chromosomal abnormality was confirmed in one patient (Down syndrome) and in one patient suspicion of Patau syndrome was found. Twelve newborns had complete cheilognathopalatoschisis. Two premature newborns and two term newborns had perinatal asphyxia. In this group of patients, 33% had respiratory insufficiency without the presence of congenital heart abnormality, 66% had congenital heart abnormality with respiratory insufficiency, and 2 patients had feeding problems. Only one patient had a positive family history. The diagnosis of complete cheilognathopalatoschisis was confirmed prenatally only in 9 patients. We confirmed that clinical consequences of congenital abnormalities of lip and palate depend on the nature, localization and range of abnormalities, as well as on the genetic background and accompanying congenital abnormalities. Prenatal confirmation of the presence of congenital abnormalities has an important influence on the postnatal management of a patient. |
| Databáze: | OpenAIRE |
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