Radiation-induced sarcoma in patients with nasopharyngeal carcinoma: a single-institution study
| Autor: | Mian Xi, Chun Fang Xie, Hai Xia Wang, Li Zhang, Ling Cai, Meng Zhong Liu, Qiao Qiao Li |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Neoplasms Radiation-Induced Time Factors Adolescent medicine.medical_treatment medicine Humans business.industry Incidence (epidemiology) Medical record Cancer Retrospective cohort study Nasopharyngeal Neoplasms Neoplasms Second Primary Sarcoma Middle Aged medicine.disease Prognosis Surgery Radiation therapy Treatment Outcome Oncology Nasopharyngeal carcinoma Osteosarcoma Female business |
| Zdroj: | Cancer. 116(23) |
| ISSN: | 0008-543X |
| Popis: | BACKGROUND: The increasing incidence of radiation-induced sarcoma (RIS) has become a significant problem that can limit long-term survival. The objective of the current study was to analyze the clinicopathologic characteristics, treatment outcomes, and prognostic factors of RIS after radiotherapy for nasopharyngeal carcinoma (NPC). METHODS: Institutional electronic medical records of patients with NPC who received definitive radiotherapy between February 1964 and 2003 were reviewed. Fifty-three patients who developed RIS and fulfilled the study criteria were included. RESULTS: The median follow-up after a diagnosis of RIS was 15.5 months (range, 0.4-90.3 months), and the median latency between radiotherapy for NPC and an RIS diagnosis was 9.3 years (range, 3.2-26.6 years). Fibrosarcoma was the most frequent histologic type observed, followed by osteosarcoma, and malignant fibrous histiocytoma. The 3-year overall survival (OS) rate for 49 patients who received treatment was 32.4%, and the median survival was 21.2 months (95% confidence interval, 8.7-33.8 months). The median OS was 41.3 months, 8.4 months, and 11 months for the complete resection group, the incomplete resection group, and the chemotherapy group, respectively (P |
| Databáze: | OpenAIRE |
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