Environment and sex control lifespan and telomere length in wild-derived African killifish
| Autor: | Milan Vrtílek, Miguel Godinho Ferreira, Kety Giannetti, Radim Blazek, Matej Polačik, Tania Ferreira, Martin Reichard |
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| Přispěvatelé: | Institute of Vertebrate Biology of the Czech Academy of Sciences (IVB / CAS), Czech Academy of Sciences [Prague] (CAS), Instituto Gulbenkian de Ciência [Oeiras] (IGC), Fundação Calouste Gulbenkian, Institute for Research on Cancer and Aging of Nice (IRCAN) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
sex differences
0303 health sciences telomere Adaptive value comparative analysis media_common.quotation_subject [SDV]Life Sciences [q-bio] Longevity Negative association Biology biology.organism_classification Telomere 03 medical and health sciences 0302 clinical medicine Nothobranchius longevity Evolutionary biology killifish Juvenile Killifish Length distribution [SDE.BE]Environmental Sciences/Biodiversity and Ecology 030217 neurology & neurosurgery 030304 developmental biology media_common |
| Popis: | Telomere length is correlated positively with longevity at the individual level, but negatively when compared across species. Here, we tested the association between lifespan and telomere length in African annual killifish. We analyzed telomere length in 18 Nothobranchius strains derived from diverse habitats and measured the laboratory lifespan of 14 strains of N. furzeri and N. kadleci. We found that males had shorter telomeres than females. The longest telomeres were recorded in strains derived from dry region where male lifespans were shortest. At the individual level, we detected a weak negative association between rapid juvenile growth and shorter telomeres in early adulthood. Overall, average telomere length was a good descriptor of telomere length distribution. However, within-individual telomere length spread was not related to any pattern. This substantial variation in telomere length between strains from different environments provides killifish as powerful tool to understand the evolutionarily adaptive value of telomere length. |
| Databáze: | OpenAIRE |
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