Influence of level and depth on recurrence rate in thin melanomas
| Autor: | Lennart H. Marx, L. Martin Jerry, Walley J. Temple, Frederick Alexander, Stephen L. Cassar, Rene Lafreniere, Shirley A. Huchcroft, Leon A. Pontikes |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Local excision Multivariate analysis Skin Neoplasms business.industry Melanoma Population General Medicine medicine.disease Prognosis Surgery Risk Factors Multivariate Analysis medicine Humans Neoplasm Invasiveness Neoplasm Recurrence Local education business Follow-Up Studies |
| Zdroj: | American journal of surgery. 165(2) |
| ISSN: | 0002-9610 |
| Popis: | A population-based study of the biology of the thin-level melanoma according to site, Breslow's thickness, and Clark's level was undertaken. Two hundred fifteen patients were studied with a mean follow-up of 41 months. Overall, 23 patients (10.7%) had recurrences, 8 locally, 9 regionally, and 6 systemically, despite an adequate local excision. A multivariate analysis was done. In the patients with thin lesions (less than 1 mm), increasing level (p0.002) and head and neck site (p0.04) increased the risk of recurrence. Increasing thickness of melanoma up to 1 mm did not influence the risk. This study identifies a group of high-risk melanoma patients for whom adjuvant therapy to decrease recurrences should be studied. |
| Databáze: | OpenAIRE |
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