New Nile Blue Derivatives as NIR Fluorescent Probes and Antifungal Agents
| Autor: | João C. C. Ferreira, M. Sameiro T. Gonçalves, Maria João Sousa, Rui P. C. L. Sousa |
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| Přispěvatelé: | Universidade do Minho |
| Rok vydání: | 2018 |
| Předmět: |
Antifungal
010405 organic chemistry medicine.drug_class Benzo[a]phenoxazines NIR fluorescent probes 010402 general chemistry Nile blue 01 natural sciences 6. Clean water 0104 chemical sciences chemistry.chemical_compound Nile Blue derivatives chemistry Regional development Research centre medicine Antifungal agents Nuclear chemistry |
| Zdroj: | 22nd International Electronic Conference on Synthetic Organic Chemistry. |
| DOI: | 10.3390/ecsoc-22-05693 |
| Popis: | The synthesis of four new Nile Blue derivatives with hydrogen, propyl and/or aminopropyl groups as substituents of the amines of 5- and 9-positions is described. Photophysical properties were evaluated in acidified ethanol and aqueous solution at physiological pH. Antifungal activity is also studied through the obtention of MIC values. Thanks are due to Fundação para a Ciência e Tecnologia (FCT) and FEDER (European Fund for Regional Development)-COMPETE-QRENEU for financial support through the Chemistry Research Centre of the University of Minho (Ref. UID/QUI/00686/2013 and UID/QUI/0686/2016), CBMA (PEst OE/BIA/UI4050/2014) and a PhD grant to J.C.F. (SFRH/BD/133207/2017). The NMR spectrometer Bruker Avance III 400 is part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project No 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). |
| Databáze: | OpenAIRE |
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