An ultrastructural analysis of platelets, erythrocytes, white blood cells, and fibrin network in systemic lupus erythematosus
| Autor: | Jeanette N. du Plooy, Etheresia Pretorius, Prashilla Soma, Armen Yuri Gasparyan |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Blood Platelets Male Pathology medicine.medical_specialty Systemic blood Erythrocytes Immunology Cell Communication Fibrin Young Adult Rheumatology Cell-Derived Microparticles Leukocytes Immunology and Allergy Medicine Humans Lupus Erythematosus Systemic In patient Platelet Platelet activation skin and connective tissue diseases Lupus erythematosus biology business.industry Platelet-Rich Plasma Thrombosis medicine.disease Platelet Activation Platelet-rich plasma Blood Buffy Coat biology.protein Ultrastructure Microscopy Electron Scanning Female business |
| Zdroj: | Rheumatology international. 34(7) |
| ISSN: | 1437-160X |
| Popis: | The study suggests that patients with systemic lupus erythematosus (SLE) present with distinct inflammatory ultrastructural changes such as platelets blebbing, generation of platelet-derived microparticles, spontaneous formation of massive fibrin network and fusion of the erythrocytes membranes. Lupoid platelets actively interact with other inflammatory cells, particularly with white blood cells (WBCs), and the massive fibrin network facilitates such an interaction. It is possible that the concerted actions of platelets, erythrocytes and WBC, caught in the inflammatory fibrin network, predispose to pro-thrombotic states in patients with SLE. |
| Databáze: | OpenAIRE |
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