Going Beyond the Debye Length: Overcoming Charge Screening Limitations in Next-Generation Bioelectronic Sensors
| Autor: | Boris Murmann, H. Tom Soh, Vladimir Kesler |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Computer science
General Physics and Astronomy FOS: Physical sciences Nanotechnology 02 engineering and technology Biosensing Techniques Applied Physics (physics.app-ph) Systems and Control (eess.SY) 010402 general chemistry 01 natural sciences Electrical Engineering and Systems Science - Systems and Control symbols.namesake Physics - Chemical Physics FOS: Electrical engineering electronic engineering information engineering General Materials Science Electronics Sensitivity (control systems) Physics - Biological Physics Debye length Ions Chemical Physics (physics.chem-ph) General Engineering Physics - Applied Physics 021001 nanoscience & nanotechnology Charge screening Physics - Medical Physics 0104 chemical sciences Biological Physics (physics.bio-ph) Perspective symbols Medical Physics (physics.med-ph) 0210 nano-technology Biosensor |
| Zdroj: | ACS Nano |
| DOI: | 10.48550/arxiv.2007.13201 |
| Popis: | Electronic biosensors are a natural fit for field-deployable diagnostic devices, because they can be miniaturized, mass produced, and integrated with circuitry. Unfortunately, progress in the development of such platforms has been hindered by the fact that mobile ions present in biological samples screen charges from the target molecule, greatly reducing sensor sensitivity. Under physiological conditions, the thickness of the resulting electric double layer is less than 1 nm, and it has generally been assumed that electronic detection beyond this distance is virtually impossible. However, a few recently-described sensor design strategies seem to defy this conventional wisdom, exploiting the physics of electrical double layers in ways that traditional models do not capture. In the first strategy, charge screening is decreased by constraining the space in which double layers can form. The second strategy uses external stimuli to prevent double layers from reaching equilibrium, thereby effectively reducing charge screening. The goal of this article is to describe these relatively new concepts, and to offer theoretical insights into mechanisms that may enable electronic biosensing beyond the double-layer. If these concepts can be further developed and translated into practical electronic biosensors, we foresee exciting opportunities for the next generation of diagnostic technologies. |
| Databáze: | OpenAIRE |
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