PD-L1 Expression Is Associated with FOXP3+ Regulatory T-Cell Infiltration of Soft Tissue Sarcoma and Poor Patient Prognosis
| Autor: | Bu Shu Xu, Yuan Xiang Guan, Huo Ying Chen, Yao Liang, Wei Xiao, Zhiwei Zhou, Shu Mei Yan, Yi Que, Qiao Qiao Li, Xing Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
PD-L1
0301 basic medicine Regulatory T cell chemical and pharmacologic phenomena 03 medical and health sciences 0302 clinical medicine Immune system medicine Soft tissue sarcoma Univariate analysis biology business.industry FOXP3 hemic and immune systems medicine.disease FOXP3+ 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis biology.protein Cancer research Immunohistochemistry prognosis business Infiltration (medical) Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| DOI: | 10.7150/jca.18683 |
| Popis: | Background: Programmed death ligand-1(PD-L1) functions as a negative mediator of immune response through different pathways in anti-tumor immunity. Recent studies have reported that PD-L1 plays a pivotal role in the function of regulatory T-cells (Tregs). Although increases in FOXP3+ Tregs infiltration and PD-L1 expression have been revealed in several cancers, their correlation with soft tissue sarcoma remains unknown. Methods: We included 163 cases of soft tissue sarcoma who were diagnosed and underwent extensive and radical resection at the Sun Yat-sen University Cancer Center, Guangzhou, China, from 2000-2010. PD-L1 and FOXP3 expression was evaluated by immunohistochemistry. Correlation between their expressions and associations with clinicopathological features were studied. Results: Among 163 STS samples, 19 (11.7%) exhibited PD-L1 positivity, and 41 (25.2%) cases expressed high FOXP3+ Treg infiltration. Significant correlation between PD-L1 expression and FOXP3+Treg infiltration in STS was identified (r=0.450, p |
| Databáze: | OpenAIRE |
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