Harnessing in situ glutathione for effective ROS generation and tumor suppression via nanohybrid-mediated catabolism dynamic therapy

Autor:	Si-Yuan Peng, Xin-Hua Liu, Qi-Wen Chen, Yun-Jian Yu, Miao-Deng Liu, Xian-Zheng Zhang
Rok vydání:	2022
Předmět:	Biomaterials Superoxides Mechanics of Materials Iron Biophysics Ceramics and Composites Bioengineering Hydrogen Peroxide Reactive Oxygen Species Selenious Acid Glutathione
Zdroj:	Biomaterials. 281:121358
ISSN:	0142-9612
Popis:	The overexpression of glutathione (GSH) in cancer cells has long been regarded as the primary obstacle for reactive oxygen species (ROS)-involved anti-tumor therapies. To solve this issue, a ferric ion and selenite-codoped calcium phosphate (Fe/Se-CaP) nanohybrid here is fabricated to catabolize endogenous GSH, instead of directly deleting it, to trigger a ROS storm for tumor suppression. The selenite component in Fe/Se-CaP can catabolize GSH to superoxide anion (O
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11583b276d0c9d146961df7af1aecb6 https://doi.org/10.1016/j.biomaterials.2021.121358 Zobrazit plný text záznamu Full Text from ScienceDirect