Split-dose sodium picosulfate–magnesium citrate colonoscopy preparation achieves lower residual gastric volume with higher cleansing effectiveness than a previous-day regimen
| Autor: | María T. Herraiz, Susana de la Riva, Miguel Muñoz-Navas, César Prieto-Frías, Luis Xavier López, Cristina Carretero, M. Betés, Ramón Angós, Alejandra Alzina |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Sodium picosulfate medicine.drug_class medicine.medical_treatment Colon cleansing Cathartic Colonoscopy Ottawa Bowel Preparation Scale Proton-pump inhibitor Gastroenterology Citric Acid Drug Administration Schedule 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Preoperative Care Organometallic Compounds medicine Humans Radiology Nuclear Medicine and imaging Citrates Endoscopy Digestive System Prospective Studies Aged medicine.diagnostic_test Cathartics business.industry Stomach Middle Aged Gastrointestinal Contents Regimen medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Anesthesia Picolines Female 030211 gastroenterology & hepatology business |
| Zdroj: | Gastrointestinal Endoscopy. 83:566-573 |
| ISSN: | 0016-5107 |
| DOI: | 10.1016/j.gie.2015.06.054 |
| Popis: | Background and Aims It is known that sodium picosulfate–magnesium citrate (SPMC) bowel preparations are effective, well tolerated and safe, and that split-dosing is more effective for colon cleansing than previous-day regimens. Anesthetic guidelines consider that residual gastric fluid is independent of clear liquid fasting times. However, reluctance to use split-dosing persists. This may be due to limited data on residual gastric fluid volumes (RGFVs) and split-dosing bowel preparations, and that these may not be perceived as standard clear liquids. Furthermore, no studies are available on RGFV/residual gastric fluid pH (RGFpH) and SPMC. We aimed to evaluate the cleansing effectiveness and the RGFV/RGFpH achieved after an SPMC split-dosing regimen compared with a SPMC previous-day regimen. Methods This was a single-center observational study. A total of 328 outpatients scheduled for simultaneous EGD and colonoscopy and following a split-dosing or previous-day regimen of SPMC were included. We prospectively measured colon cleanliness by using the Ottawa Bowel Preparation Scale, RGFV, and RGFpH. Results Ottawa Bowel Preparation Scale scores for overall, right, mid-colon, and colon fluid were significantly better in the split-dosing group. In the split-dosing group, the 3- to 4-hour fasting time consistently achieved the best cleansing quality. RGFV was significantly lower in the split-dosing group (11.09 vs 18.62, P Conclusions Split-dosing SPMC provides higher colon cleansing quality with lower RGFVs than previous-day SPMC regimens. SPMC in split-dosing acts exactly as a standard clear liquid acts, and thus anesthetic guidelines on this issue may be applied with no concerns. |
| Databáze: | OpenAIRE |
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