Fractures and phenylketonuria
| Autor: | Dennis Carson, Christopher Patterson, Magee A, Greeves Lg |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
medicine.medical_specialty Bone disease Adolescent Fractures Bone Bone Density Risk Factors Internal medicine Phenylketonurias medicine Humans Sibling Child business.industry Incidence (epidemiology) Age Factors Infant General Medicine medicine.disease Confidence interval Surgery Osteopenia El Niño Relative risk Child Preschool Pediatrics Perinatology and Child Health Lifetime risk business Diet Therapy |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 86(3) |
| ISSN: | 0803-5253 |
| Popis: | Parent or self-reported history of fractures in a group of patients aged from 0.3 to 33.6 years on dietary treatment for phenylketonuria was studied by means of a questionnaire. Twenty-one of 85 patients had a history of fracture compared with 18/98 sibling controls. There was no significant difference in the lifetime risk of fracture between patients and controls (chi 2 = 1.43, df = 1, p = 0.23), but a significantly higher risk of fracture was reported over the age of 8 y (chi 2 = 5.11, df = 1, p = 0.024), with a relative risk of 2.6 (95% confidence interval 1.1.6.1). We suggest this may be related either to deterioration in dietary control in this age group or to a cumulative disease-related or diet-related reduction in bone mass. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text