Occupational airborne contact urticaria, anaphylaxis and asthma in farmers and agronomists due toBruchus pisorum

Autor:	Miriam Castillo, Fernando Pineda, Blanca Martín, Abel Barrios, Rafael Álvarez, Alicia Armentia, Víctor Moreno-González, S. Martin, Sara Garrido Fernández, Angela Moro, José María Vega
Rok vydání:	2020
Předmět:	Adult Male Allergy Provocation test Dermatology medicine.disease_cause 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Allergen immune system diseases Food allergy medicine Humans Immunology and Allergy 030212 general & internal medicine Anaphylaxis Skin Tests Asthma Farmers Inhalation business.industry food and beverages Outbreak Fabaceae Immunoglobulin E Middle Aged medicine.disease respiratory tract diseases Dermatitis Allergic Contact Immunology Female business Food Hypersensitivity
Zdroj:	Contact Dermatitis. 83:466-474
ISSN:	1600-0536 0105-1873
DOI:	10.1111/cod.13644
Popis:	Background Occupational contact urticaria due to inhalation of legume pest allergens has rarely been described. Objective To determine the cause of an outbreak of airborne contact urticaria, asthma, and anaphylaxis in farmers and agronomists studying the disinsectization of dried peas. Peas were treated with aluminum phosphide (EPA). Methods Extracts prepared from Bruchus lentis and Bruchus pisorum bodies and from healthy legumes, EPA-treated legumes, and infested legumes, were used for in vivo tests (skin prick testing, oral, and specific bronchial challenge for the diagnosis of asthma and anaphylaxis) in affected patients and in five control patients with severe legume hypersensitivity. Open application, patch testing with the most common legume insecticides, molecular analysis, and IgE immunoblotting were undertaken. Results We found positive responses (prick, provocation, immune detection) to parasitic pea extracts and B. pisorum. A 25 kDa band was detected in the western blot of all patients who worked with infested EPA-treated peas. Bands from B. pisorum extract were detected in all patients. No responses to pea allergens were found in any patient, unlike in legume allergy controls. Oral provocation tests were negative. Conclusion B. pisorum is a cause of contact urticaria and may cause occupational hives, anaphylaxis, and asthma. The allergen may enter by inhalation or puncture of setae released by B. pisorum. HIGHLIGHTS : Allergic reactions may be caused by inhaling legume dust or vapors, but occupational allergy after inhalation or contact of legume pest allergens has rarely been described. Bruchus pisorum is an allergenic source that may cause occupational urticaria, anaphylaxis, and asthma. To the best of our knowledge, this is the first report on allergy caused by this invasive species Pea pest proteins may cause IgE-mediated allergy in patients inhaling infested pea particles. Agronomists, cooks, farmers, and grocery workers are occupational populations at risk.
Databáze:	OpenAIRE
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