Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia
| Autor: | José Mayans, Cristina Reinoso Martín, Carlos García Ballesteros, Rosa Farrás Rivera, David Montaner, Eloisa Jantus Lewintre, Javier García-Conde |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
medicine.medical_specialty Chronic lymphocytic leukemia IgV(H) ZAP70 LPL IgVH Immunoglobulin E CIENCIAS MÉDICAS ::Patología::Hematología [UNESCO] Prognostic marker Predictive Value of Tests Internal medicine medicine Humans UNESCO::CIENCIAS MÉDICAS ::Patología::Hematología RNA Messenger Stage (cooking) Hematology biology Flavoproteins ZAP70 Cancer Cryptochrome-1 medicine.disease Prognosis CIENCIAS MÉDICAS [UNESCO] Leukemia Lymphocytic Chronic B-Cell Cryptochromes Leukemia UNESCO::CIENCIAS MÉDICAS ::Patología::Oncología Immunology UNESCO::CIENCIAS MÉDICAS biology.protein Brief Reports Antibody LPL CIENCIAS MÉDICAS ::Patología::Oncología [UNESCO] Biomarkers |
| Zdroj: | JANTUS LEWINTRE, Eloisa ; Reinoso Martín, Cristina ; García Ballesteros, Carlos ; Montaner Gonzalez, David ; Farrás Rivera, Rosa ; Mayans, José Ramón ; García-Conde, Javier, 2008, Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia, Haematologica, vol. 94, no. 2, p. 280-284 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname HAEMATOLOGICA r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) JANTUS LEWINTRE, Eloisa ; Reinoso Martín, Cristina ; García Ballesteros, Carlos ; Montaner Gonzalez, David ; Farrás Rivera, Rosa ; Mayans, José Ramón, García-Conde, Javier, Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia, Haematologica, vol. 94, no. 2, p. 280-284 r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) Centro de Investigación Principe Felipe (CIPF) |
| ISSN: | 0390-6078 |
| Popis: | Chronic lymphocytic leukemia is an adult-onset leukemia with a heterogeneous clinical behavior. When chronic lymphocytic leukemia cases were divided on the basis of IgVH mutational status, widely differing clinical courses were revealed. Since IgVH sequencing is difficult to perform in a routine diagnostic laboratory, finding a surrogate for IgVH mutational status seems an important priority. In the present study, we proposed the use of Cryptochrome- 1 as a new prognostic marker in early-stage chronic lymphocytic leukemia. Seventy patients (Binet stage A, without treatment) were included in the study. We correlated Cryptochrome-1 mRNA with well established prognostic markers such as IgVH mutations, ZAP70, LPL or CD38 expression and chromosomal abnormalities. High Cryptochrome-1 expression correlated with IgVH unmutated samples. In addition, Cryptochrome-1 was a valuable predictor of disease progression in early stage chronic lymphocytic leukemia, therefore it can be introduced in clinical practice with the advantage of a simplified method of quantification. Montaner Gonzalez, David, David.Montaner@uv.es |
| Databáze: | OpenAIRE |
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