Plasma levels of nerve growth factor in Egyptian autistic children: Relation to hyperserotonemia and autoimmunity
Autor: | Gehan A. Mostafa, Mahmoud Maher, Nagwa A. Meguid, Amal Elsaeid, Abeer Al Sayed Shehab |
---|---|
Rok vydání: | 2021 |
Předmět: |
Male
medicine.medical_specialty Serotonin Immunology Autoimmunity medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Internal medicine Nerve Growth Factor medicine Immunology and Allergy Humans Autistic Disorder Child Autoantibodies biology business.industry Autoantibody Plasma levels Mast cell medicine.disease medicine.anatomical_structure Nerve growth factor Endocrinology Cross-Sectional Studies Neurology Child Preschool biology.protein Autism Egypt Female Neurology (clinical) Antibody business 030217 neurology & neurosurgery Biomarkers 030215 immunology Follow-Up Studies |
Zdroj: | Journal of neuroimmunology. 358 |
ISSN: | 1872-8421 |
Popis: | Hyperserotonemia and brain-specific autoantibodies are detected in some autistic children. Nerve growth factor (NGF) stimulates the proliferation of B lymphocytes with production of antibodies and also increases mast cell serotonin release. This work was the first to investigate the relationship between plasma NGF and both hyperserotonemia and the frequency of serum anti-myelin basic protein (anti-MBP) auto-antibodies in 22 autistic children aged between 4 and 12 years and 22 healthy-matched controls. Levels of NGF, serotonin and anti-MBP were significantly higher in autistic children than healthy control children (P 0.001). There was a significant positive correlation between NGF and serotonin levels in autistic patients (P 0.01). In contrast, there was a non-significant correlation between NGF and anti-MBP levels (P 0.05). In conclusions, serum NGF levels were elevated and significantly correlated to hyperserotonemia found in many autistic children. |
Databáze: | OpenAIRE |
Externí odkaz: |