The role of ectopic germinal centers in the immunopathology of primary Sjögren's syndrome: a systematic review
| Autor: | Joel A G van Roon, Marjolein F Looije, Anna P. Risselada, Aike A. Kruize, Johannes W. J. Bijlsma |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Lymphocyte Disease Choristoma Gastroenterology Severity of Illness Index Salivary Glands stomatognathic system Rheumatology Immunopathology Statistical significance Internal medicine Severity of illness medicine Rheumatoid factor Humans business.industry Germinal center medicine.disease Germinal Center Lymphoma stomatognathic diseases Anesthesiology and Pain Medicine medicine.anatomical_structure Sjogren's Syndrome Immunology business |
| Zdroj: | Seminars in arthritis and rheumatism. 42(4) |
| ISSN: | 1532-866X |
| Popis: | Objectives To determine whether the presence of germinal centers (GCs) in salivary glands of patients with primary Sjogren's syndrome (pSS) is related to the severity of disease course and distinct immunopathology features. Methods A systematic search was performed in September 2011 for terms and synonyms of Sjogren's syndrome and germinal centers. A total of 80 articles were retrieved, of which 16 were included for (meta-) analysis. Results GC morphology was present in a mean ± SD 25.1 ± 5.0% of pSS patients. Mean lymphocyte focus scores were 1.25 points higher in patients with GCs as compared to those without GCs. Saliva production was reduced in patients with GCs, although this did not reach statistical significance. Percentages of patients positive for rheumatoid factor, anti-Sjogren's syndrome A (SSA), and anti-Sjogren's syndrome B (SSB) antibodies were significantly higher in patients with GCs (mean increase, 15%, 18%, and 18%, respectively). Additionally, patients with GCs were characterized by enhanced levels of local and systemic proinflammatory mediators. Importantly, these patients have a higher risk of lymphoma development (14% versus 1%). Conclusions Patients with GCs are characterized by more severe disease, although the small number of studies and their design hamper generalizability of results. The precise mechanisms that contribute to the development and persistence of germinal centers in pSS are largely unknown. This and the strongly increased risk of lymphoma development warrant intensive studies for the role of germinal centers in the immunopathology of pSS. |
| Databáze: | OpenAIRE |
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