Focal cerebral ischemia-induced escape deficit in rats is ameliorated by a reversible inhibitor of monoamine oxidase-a: implications for a novel animal model of post-stroke depression
| Autor: | Masahito Okamoto, Taketoshi Ishii, Hiroshi Iwata, Hiroshi Narita, Masaya Kato |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Monoamine Oxidase Inhibitors Monoamine oxidase Pharmaceutical Science Escape response Brain Ischemia Brain ischemia Escape Reaction medicine.artery Internal medicine medicine Post-stroke depression Animals Monoamine Oxidase Pharmacology biology business.industry Depression General Medicine medicine.disease Rats Disease Models Animal Monoamine neurotransmitter Endocrinology Anesthesia Middle cerebral artery Catecholamine biology.protein Monoamine oxidase A business medicine.drug |
| Zdroj: | Biologicalpharmaceutical bulletin. 23(4) |
| ISSN: | 0918-6158 |
| Popis: | The present investigation was conducted to examine whether a reversible inhibitor of monoamine oxidase (MAO)-A, T-794, affects the shuttle-box escape deficit induced by transient middle cerebral artery (MCA) occlusion (MCAO). MCA-occluded and sham-operated rats (surgery on day 0) were subjected to daily shuttle-box session from day 7 to 9 (training series) and from day 13 to 15 (test series) and received twice daily administration of T-794 (10 mg/kg p.o., b.i.d.) or vehicle from the evening of day 9. In the final shuttle-box session of test series (day 15), while MCA-occluded-vehicle-treated rats showed significantly more escape failures than sham-operated-vehicle-treated rats, the failures made by MCA-occluded rats were significantly decreased by T-794 to the level of the sham-operated group. Additionally, biochemical examination was conducted after behavioral evaluation to examine possible involvement of the brain monoamine system in the observed behavioral syndrome. In occluded hemisphere of MCA-occluded rats, catecholamine levels were decreased and ratios of deaminated metabolite to corresponding monoamine were increased compared with the respective values of the sham-operated group, and these changes were reversed by T-794. Results are discussed in terms of possible relevance of the MCAO-induced escape deficit to post-stroke depression. |
| Databáze: | OpenAIRE |
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