Turning the spotlight on the oligosaccharide chain of GM1 ganglioside
| Autor: | Nicoletta Loberto, Laura Mauri, Maria Fazzari, Giulia Lunghi, Elena Chiricozzi, Massimo Aureli, Erika Di Biase, Sandro Sonnino |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Ceramide
Oligosaccharides Neurodifferentiation Drug development G(M1) Ganglioside Subcellular Fraction Biochemistry Neuroprotection 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine GM1 oligosaccharide medicine Animals Humans Neurodegeneration Receptor trkA Comprehensive Review Article Molecular Biology 030304 developmental biology chemistry.chemical_classification Neurons 0303 health sciences Cell Differentiation Neurodegenerative Diseases Cell Biology Glycosphingolipid Oligosaccharide medicine.disease Gm1 ganglioside Cell biology Mitochondria carbohydrates (lipids) Membrane protein chemistry Parkinson’s disease lipids (amino acids peptides and proteins) 030217 neurology & neurosurgery |
| Zdroj: | Glycoconjugate Journal |
| ISSN: | 1573-4986 0282-0080 |
| Popis: | It is well over a century that glycosphingolipids are matter of interest in different fields of research. The hydrophilic oligosaccharide and the lipid moiety, the ceramide, both or separately have been considered in different moments as the crucial portion of the molecule, responsible for the role played by the glycosphingolipids associated to the plasma-membranes or to any other subcellular fraction. Glycosphingolipids are a family of compounds characterized by thousands of structures differing in both the oligosaccharide and the ceramide moieties, but among them, the nervous system monosialylated glycosphingolipid GM1, belonging to the group of gangliosides, has gained particular attention by a multitude of Scientists. In recent years, a series of studies have been conducted on the functional roles played by the hydrophilic part of GM1, its oligosaccharide, that we have named “OligoGM1”. These studies allowed to shed new light on the mechanisms underlying the properties of GM1 defining the role of the OligoGM1 in determining precise interactions with membrane proteins instrumental for the neuronal functions, leaving to the ceramide the role of correctly positioning the GM1 in the membrane crucial for the oligosaccharide-protein interactions. In this review we aim to report the recent studies on the cascade of events modulated by OligoGM1, as the bioactive portion of GM1, to support neuronal differentiation and trophism together with preclinical studies on its potential to modify the progression of Parkinson’s disease. |
| Databáze: | OpenAIRE |
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