Spontaneous pregnancies in female survivors of childhood allogeneic haemopoietic stem cell transplant for haematological malignancies
| Autor: | Samantha Lai-Ka Lee, Margaret Zacharin, Karin Tiedemann |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty Cyclophosphamide Endocrinology Diabetes and Metabolism media_common.quotation_subject medicine.medical_treatment 030209 endocrinology & metabolism Fertility Hematopoietic stem cell transplantation 03 medical and health sciences 0302 clinical medicine Endocrinology Pregnancy Internal medicine Humans Medicine Survivors Retrospective Studies media_common Chemotherapy business.industry Medical record Hematopoietic Stem Cell Transplantation Retrospective cohort study Total body irradiation medicine.disease Hematologic Neoplasms 030220 oncology & carcinogenesis Female business Whole-Body Irradiation medicine.drug |
| Zdroj: | Clinical Endocrinology. 93:466-472 |
| ISSN: | 1365-2265 0300-0664 |
| Popis: | OBJECTIVE: Spontaneous pregnancies and live births are rarely reported after haematopoietic stem cell transplant (HSCT). We report spontaneous pregnancy outcomes of sexually active female survivors of childhood allogeneic HSCT, to provide more data for future counselling. DESIGN, PATIENTS AND MEASUREMENTS: Retrospective review of all female survivors of childhood haematological malignancies who had allogeneic HSCT at the Royal Children Hospital between 1985 and 2011. Data were retrieved from medical records, updated from treating haematologist or endocrinologist, and were cross-referenced with self-reported questionnaires. Female survivors who were sexually inactive were excluded from analysis. RESULTS: Six of 37 (16.2%) female survivors reported spontaneous pregnancies resulting in 8 live births. Amongst 22 women who received total body irradiation (n = 21) ± cranial irradiation or isolated cranial irradiation (n = 1), and high-dose cyclophosphamide, three reported pregnancy resulting in live births (14%), whilst three of 15 women who received chemotherapy alone had pregnancy with live births (20%). CONCLUSIONS: Our current finding, albeit a small sample size, reinforces the importance of counselling female survivors of HSCT about the possibility of spontaneous pregnancy occurring despite documented ovarian failure and for need of contraception to avoid unplanned pregnancy. |
| Databáze: | OpenAIRE |
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