Human alveolar bone cell adhesion and growth on ion-implanted titanium
| Autor: | Saima N. Nayab, Irwin Olsen, FH Jones |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Titanium
Materials science Biocompatibility Biomedical Engineering chemistry.chemical_element Biocompatible Materials Bone healing Cell morphology Osteocytes Osseointegration Biomaterials chemistry Bone cell Cell Adhesion Microscopy Electron Scanning Potassium Calcium Microscopy Phase-Contrast Argon Cell adhesion Dental alveolus Biomedical engineering |
| Zdroj: | Journal of Biomedical Materials Research. :651-657 |
| ISSN: | 1097-4636 0021-9304 |
| Popis: | Surface characteristics play a vital role in determining the biocompatibility of materials used as bone implants. Calcium ion implantation of titanium was previously reported to enhance osseointegration and bone formation in vivo, although the lack of consistent and reproducible effects highlight the need to understand the basic mechanisms involved in the response of target cells to such surfaces. The aim of this study was therefore to measure the precise effects of ion implantation of titanium on bone cells in vitro. Alveolar bone cells were seeded on the surface of polished titanium disks implanted with calcium, potassium, and argon ions. Using radioisotopically tagged bone cells, the results showed that although the calcium ion implanted surface reduced cell adhesion, it nevertheless significantly enhanced cell spreading and subsequent cell growth. In contrast, few differences in bone cell behavior were observed between the potassium- and argon-implanted titanium and the control nonimplanted titanium disks. These findings suggest the possibility that the calcium-implanted surface may significantly affect the biocompatibility of titanium implants by enhancing bone cell growth. Surface modification by ion implantation could thus prove to be a valuable tool for improving the clinical efficacy of titanium for bone repair and regeneration in vivo. (C) 2004 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|