Activation and inactivation of 3-hydroxy-3-methylglutaryl coenzyme a reductase in aged rat liver
| Autor: | Kiyohisa Uchida, Yoshiaki Katayama, Masafumi Koga, Nozomu Takeuchi, Hitoshi Kukita |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
Aging medicine.medical_specialty Coenzyme A Reductase Biochemistry chemistry.chemical_compound Enzyme activator Adenosine Triphosphate Cytosol Endocrinology Internal medicine Genetics medicine Animals Magnesium Molecular Biology chemistry.chemical_classification Activator (genetics) Cell Biology Hydroxymethylglutaryl-CoA reductase Rats Enzyme Activation Enzyme Liver chemistry Microsomes Liver Hydroxymethylglutaryl CoA Reductases Adenosine triphosphate |
| Zdroj: | Experimental Gerontology. 15:15-23 |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/0531-5565(80)90019-4 |
| Popis: | Activation and inactivation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is a key enzyme of cholesterol synthesis, were examined in young and aged rats in vitro . The reductase activity in the liver microsomes of aged rats was always lower than that of young rats at various experimental conditions in vitro . But activation and inactivation of the reductase could operate on liver microsomes in aged rats as well as in young rats. Function of hepatic cytosol activator in aged rats seemed to be identical to that in young rats. |
| Databáze: | OpenAIRE |
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