Testosterone reduces generosity through cortical and subcortical mechanisms
| Autor: | Yang Hu, Xiaoxue Gao, Jianxin Ou, Yin Wu, Philippe N. Tobler, Hong Li |
|---|---|
| Přispěvatelé: | University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Generosity
Male medicine.drug_class media_common.quotation_subject Temporoparietal junction Decision Making temporoparietal junction Social Sciences androgen social cognition Social preferences 03 medical and health sciences 0302 clinical medicine 10007 Department of Economics prosocial behavior Social cognition medicine Humans Testosterone Social Behavior 030304 developmental biology media_common Cerebral Cortex 1000 Multidisciplinary 0303 health sciences Brain Mapping Multidisciplinary Testosterone (patch) Androgen Magnetic Resonance Imaging 330 Economics medicine.anatomical_structure Prosocial behavior Case-Control Studies Psychology Altruistic preferences Neuroscience Insula 030217 neurology & neurosurgery Personality |
| Zdroj: | Proc Natl Acad Sci U S A |
| Popis: | Recent evidence has linked testosterone, a major sex hormone, to selfishness in economic decision-making. Here, we aimed to investigate the neural mechanisms through which testosterone reduces generosity by combining functional MRI with pharmacological manipulation among healthy young males in a double-blind, placebo-controlled, between-subject design. After testosterone or placebo gel administration, participants performed a social discounting task in which they chose between selfish options (benefiting only the participant) and generous options (providing also some benefit to another person at a particular social distance). At the behavioral level, testosterone reduced generosity compared to the placebo. At the neural level (n = 60), the temporoparietal junction (TPJ) encoded the other-regarding value of the generous option during generous choices, and this effect was attenuated by testosterone, suggesting that testosterone reduced the consideration of other’s welfare as underpinned by TPJ activity. Moreover, TPJ activity more strongly reflected individual differences in generosity in the placebo than the testosterone group. Furthermore, testosterone weakened the relation between the other-regarding value of generous decisions and connectivity between the TPJ and a region extending from the insula into the striatum. Together, these findings suggest that a network encompassing both cortical and subcortical components underpins the effects of testosterone on social preferences. |
| Databáze: | OpenAIRE |
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