Anti-implantation activity of H2receptor blockers and meloxicam, a COX-inhibitor, in albino Wistar rats
| Autor: | Shyam Sundar Agrawal, M. Alvin Jose |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Thiazines
Administration Oral Pharmacology Meloxicam Ranitidine chemistry.chemical_compound Contraceptive Agents Pregnancy In vivo medicine Animals Vaginal smear Cyclooxygenase Inhibitors Pharmacology (medical) Embryo Implantation Rats Wistar Dose-Response Relationship Drug business.industry Obstetrics and Gynecology Famotidine Mast cell Rats Thiazoles Dose–response relationship medicine.anatomical_structure Histamine H2 Antagonists Reproductive Medicine chemistry Drug Therapy Combination Female business Histamine medicine.drug |
| Zdroj: | The European Journal of Contraception & Reproductive Health Care. 14:444-450 |
| ISSN: | 1473-0782 1362-5187 |
| Popis: | To evaluate the anti-implantation activity of H(2) receptor blockers ranitidine and famotidine, and Cox-inhibitor meloxicam, alone and in combination, considering the role of histamine and prostaglandins in implantation.The drugs were administered orally to female albino Wistar rats at different dose levels for 1 to 7 days, immediately after confirming copulation by observing sperm in the vaginal smear. A laparotomy was done on the 10th day of pregnancy, the implants and corpora lutea were counted, and the pre- and post implantation losses determined. The mast cell stabilising activity was studied using both in vitro and in vivo methods.Ranitidine 70 mg/kg (75.41%; p0.01), and famotidine 80 mg/kg (74.30%; p0.001) showed significant anti-fertility activity. No increase in activity was seen at higher doses. Meloxicam showed significant activity at doses of 3, 4, and 5 mg/kg. The combination of meloxicam (4 mg/kg) with ranitidine (70 mg) and famotidine (80 mg/kg) showed 100% anti-fertility activity.Our results indirectly confirm the combined involvement of histamine and prostaglandins in the implantation process. The mast cell stabilising property of H(2) blockers appears to be a possible mechanism for their anti-implantation activity. |
| Databáze: | OpenAIRE |
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