Pharmacokinetics of alfaxalone infusions, context-sensitive half-time and recovery times in male neutered cats
| Autor: | Bruno H Pypendop, Kirby Pasloske, M.G. Ranasinghe |
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| Rok vydání: | 2018 |
| Předmět: |
Male
040301 veterinary sciences Pregnanediones 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Bolus (medicine) Pharmacokinetics 030202 anesthesiology medicine Animals Infusions Intravenous CATS General Veterinary business.industry Alfaxalone Drug administration 04 agricultural and veterinary sciences Intravenous Infusions Anesthesia Anesthesia Recovery Period Plasma concentration Anesthesia Intravenous Cats business Anesthetics Intravenous Half-Life medicine.drug Half time |
| Zdroj: | Veterinary Anaesthesia and Analgesia. 45:630-639 |
| ISSN: | 1467-2987 |
| DOI: | 10.1016/j.vaa.2018.06.003 |
| Popis: | Objectives To determine the context-sensitive half-time of alfaxalone following intravenous infusions of various durations. To estimate the time necessary for plasma concentration to decrease by up to 95%. Study design Prospective randomized and simulation studies. Animals A group of six 1-year-old male castrated research cats. Methods Cats were instrumented with catheters in a jugular and a medial saphenous vein. Alfaxalone was administered using a target-controlled infusion system, to target a plasma alfaxalone concentration of 7.6 mg L–1. The infusion lasted 30 (n = 2), 60 (n = 2) or 240 (n = 2) minutes. Blood samples were collected prior to drug administration, and at several times during and up to 8 hours after the infusion, for the determination of plasma alfaxalone concentration using liquid chromatography/tandem mass spectrometry. Compartment models were fitted to each time–concentration profile, and a population model was fitted to data from all individuals. The context-sensitive half-time was determined from each individual model. In addition, times for plasma alfaxalone concentration to decrease by 50–95% following bolus administration and target-controlled infusions or continuous rate infusions of 0.5–8 hours were estimated by simulation using the population model. Results Context-sensitive half-times were 2 and 8, 6 and 9, and 18 and 20 minutes for the 30, 60 and 240 minutes, respectively. Time for plasma alfaxalone concentration to decrease by 90% was predicted to range from 7 to 120 or 113 minutes following a bolus to an 8 hour target-controlled or continuous rate infusion, respectively. Conclusion and clinical relevance Recovery time from alfaxalone anesthesia in cats is predicted to be influenced by the duration of target-controlled infusion. |
| Databáze: | OpenAIRE |
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