Autor: |
Hidenori Ogawa, Hiroshi Yamashita, Toyoki Mori, Hisashi Miyamoto, Michiaki Tominaga, Yoshitaka Yamamura, Kazumi Kondo, Kenji Nakaya, Toshiyuki Onogawa, Shigeki Nakamura, Kazuyoshi Kitano, Michinori Tanaka |
Rok vydání: |
1999 |
Předmět: |
|
Zdroj: |
Bioorganic & Medicinal Chemistry. 7:1743-1754 |
ISSN: |
0968-0896 |
Popis: |
We previously reported a series of benzazepine derivatives as orally active nonpeptide arginine vasopressin (AVP) V2 receptor antagonists. After the lead structure OPC-31260 was structurally evaluated and optimized, the introduction of the 7-Cl moiety on the benzazepine and 2-CH3 on the aminobenzoyl moiety enhanced its oral activity. The new AVP-V2 selective antagonist OPC-41061 was determined to be a potent and orally active agent. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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