NOVEL MECHANISM FOR THE SUSTAINED DURABILITY OF PROPROTEIN CONVERTASE SUBTILISIN-KEXIN TYPE 9 MONOCLONAL ANTIBODY LY3015014

Autor:	Victor J. Wroblewski, Mark C. Kowala, Bomie Han, Patrick I. Eacho, Thomas P. Beyer, Krista Schroeder, Ryan John Hansen, Richard Todd Pickard
Rok vydání:	2015
Předmět:	Ldl cholesterol animal structures medicine.drug_class business.industry PCSK9 fungi Subtilisin Proprotein convertase Monoclonal antibody Molecular biology Epitope medicine Kexin lipids (amino acids peptides and proteins) business Cardiology and Cardiovascular Medicine
Zdroj:	Journal of the American College of Cardiology. 65(10)
ISSN:	0735-1097
DOI:	10.1016/s0735-1097(15)61577-7
Popis:	Monoclonal antibodies (Mabs) that neutralize proprotein convertase subtilisin-kexin type 9 (PCSK9) cause remarkable LDL cholesterol (LDL-C) lowering in human trials. It was reported that the efficacy is determined by the epitope of the PCSK9 Mab. Here we describe a novel mechanism by which the
Databáze:	OpenAIRE
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