Remdesivir—Bringing Hope for COVID-19 Treatment
| Autor: | Ladislav Novotny, Adel Al-Hunayan, Naser F. Al-Tannak |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Exonuclease
lcsh:RS1-441 Pharmaceutical Science RNA-dependent RNA polymerase remdesivir Disease medicine.disease_cause endonuclease lcsh:Pharmacy and materia medica WHO 03 medical and health sciences 0302 clinical medicine medicine 030212 general & internal medicine 030304 developmental biology Coronavirus 0303 health sciences biology business.industry COVID-19 RNA Prodrug medicine.disease Virology biology.protein Proofreading Middle East respiratory syndrome GS-5734 business |
| Zdroj: | Scientia Pharmaceutica, Vol 88, Iss 29, p 29 (2020) |
| ISSN: | 2218-0532 |
| DOI: | 10.3390/scipharm88020029 |
| Popis: | At the beginning of 2020, the world was swept with a wave of a new coronavirus disease, named COVID-19 by the World Health Organization (WHO 2). The causative agent of this infection is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The data available on one of the promising therapeutic agents—nucleotide analog remdesivir (Gilead Sciences number GS-5734)—were evaluated. These data were concerned with remdesivir activation from the prodrug to the active molecule—triphosphate containing 1′-cyano group and modified nucleobase. This triphosphate competes with the natural substrate adenosine triphosphate. Additionally, its mechanisms of action based on RNA and proofreading exonuclease inhibition, leading to the delayed RNA chain termination of infected cells, and basic pharmacological data were assessed. Additionally, the analytical determination of remdesivir and its metabolites in cells and body liquids and also some data from remdesivir use in other RNA infections—such as Ebola, Nipah virus infection, and Middle East Respiratory Syndrome (MERS)—were summarized. More recent and more detailed data on the clinical use of remdesivir in COVID-19 were reported, showing the intensive efforts of clinicians and scientists to develop a cure for this new disease. Remdesivir as such represents one of the more promising alternatives for COVID-19 therapy, however the current understanding of this disease and the possible ways of dealing with it requires further investigation. |
| Databáze: | OpenAIRE |
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