The Effects of Egg-Derived Antibodies to Glucosyltransferases on Dental Caries in Rats
| Autor: | William H. Bowen, A.M. Vacca Smith, C Krüger, Sandra Pearson, Y Kodama, L Hammarström |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
food.ingredient
medicine.medical_treatment Immunoglobulins Virulence Dental Caries Statistics Nonparametric Microbiology Rats Sprague-Dawley Streptococcus mutans Glucosyltransferases food stomatognathic system Yolk medicine Animals General Dentistry Analysis of Variance biology Streptococcal Vaccines Immunization Passive Immunotherapy biology.organism_classification Antibodies Bacterial Egg Yolk Cariostatic Agents Rats Specific Pathogen-Free Organisms Smooth surface stomatognathic diseases Immunization embryonic structures biology.protein Female Antibody Chickens |
| Zdroj: | Caries Research. 38:9-14 |
| ISSN: | 1421-976X 0008-6568 |
| DOI: | 10.1159/000073914 |
| Popis: | The role of Streptococcus mutans in the development of dental caries is well recognized. Important virulence factors include the glucosyltransferases (gtf), essential for production of glucans. We evaluated the anticariogenic effects of orally administered chicken anti-cell-associated (CA) Gtf antibodies in desalivated rats. The animals were infected with S. mutans MT8148R and treated with chicken anti-CA-Gtf egg yolk antibodies (IgY) or nonimmune egg yolk powder. Smooth surface lesions were significantly lower in the anti-CA-Gtf-treated group in comparison to the control groups. Sulcal surface caries was also decreased and of less severity. Our study suggests that chicken anti-CA-Gtf antibodies may have promise as a prophylaxis for high caries risk patients. |
| Databáze: | OpenAIRE |
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