Electrochemical oxidation of hydroxylated phenothiazine and imipramine derivatives
| Autor: | Marilyn Neptune, Richard L. McCreery, Albert A. Manian |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
chemistry.chemical_classification
Imipramine Quinones Hydroxylation Electrochemistry Combinatorial chemistry chemistry.chemical_compound Drug activity chemistry Phenothiazines Phenothiazine Drug Discovery medicine Molecular Medicine Chlorpromazine Oxidation-Reduction Tricyclic medicine.drug Promazine |
| Zdroj: | Journal of Medicinal Chemistry. 22:196-199 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00188a014 |
| Popis: | The electrochemical oxidations of several hydroxylated derivatives of promazine, chlorpromazine, imipramine, and 3-chloroimipramine are examined and compared. Oxidation of the monohydroxyphenothiazine derivatives leads to both dihydroxy species and substituted benzoquinones, while oxidation of hydroxylated imipramines leads to only the corresponding benzoquinones. The oxidation potentials of 17 tricyclic psychoactive drugs and metabolites are tabulated and compared. The potential importance of these results to drug activity and side effects is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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