Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury
| Autor: | Irene Zini, Marta Mangifesta, Sabrina Duranti, Francesca Turroni, Rosaria Anzalone, Leonardo Mancabelli, Simona Bertoni, Alice Viappiani, Anna Maria Cantoni, Douwe van Sinderen, Valentina Vivo, Christian Milani, Elisabetta Barocelli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Neutrophils ved/biology.organism_classification_rank.species Ischemia lcsh:Medicine Pharmacology Kidney law.invention Feces Mice 03 medical and health sciences Probiotic law Immunity Malondialdehyde medicine Animals lcsh:Science Lung Bifidobacterium bifidum PRL2010 Gut microbiome Multidisciplinary Bifidobacterium bifidum Innate immune system Tumor Necrosis Factor-alpha ved/biology business.industry Probiotics lcsh:R Human health Kidney metabolism Intestinal ischemia/reperfusion injury medicine.disease Immunity Innate Interleukin-10 Intestines Disease Models Animal 030104 developmental biology Liver Mesenteric ischemia Reperfusion Injury lcsh:Q Female business Reperfusion injury |
| Zdroj: | PLoS ONE, Vol 13, Iss 8, p e0202670 (2018) |
| Popis: | Mesenteric ischemia/reperfusion is a clinical emergency with high morbidity and mortality due to the transient reduction of blood supply to the bowel. In recent years, the critical contribution of gut microbiome to human health and proper gastrointestinal functions has gradually emerged. In the current study, we investigated the protective effects of five days supplementation with Bifidobacterium bifidum PRL2010 in a murine model of gut ischemia/reperfusion. Our findings indicate that animals pretreated with B. bifidum PRL2010 showed lower neutrophil recruitment in the lungs, remarkably reduced bacterial translocation and decreased transcription levels of TNFalpha and IL-10 both in liver and kidneys, at the same time increasing those of IL-12 in kidneys. Inhibiting the adhesion of pathogenic bacteria and boosting host innate immunity responses are among the possible protective mechanisms enacted by the probiotic. These results demonstrate that short-period treatment with B. bifidum PRL2010 is a potential strategy to dampen remote organ injury due to mesenteric ischemia/reperfusion. |
| Databáze: | OpenAIRE |
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