Trends in diagnosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in India: A report of multicenter data from a web-based registry
| Autor: | S. S. Sikora, R. Shah, Debanshu Bhaduri, Puneet Dhar, Verushka Chhabra, J. Palepu, Bhawna Sirohi, R.A. Sastry, Shailesh V. Shrikhande |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Abdominal pain Pediatrics medicine.medical_specialty Time Factors Adolescent Databases Factual Histopathological grading India Neuroendocrine tumors Asymptomatic Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Sex Factors Internal medicine medicine Humans Multicenter Studies as Topic Registries Aged Gastrointestinal Neoplasms Aged 80 and over Internet business.industry Gastroenterology Hepatology Middle Aged medicine.disease Pancreatic Neoplasms Neuroendocrine Tumors 030220 oncology & carcinogenesis Cohort 030211 gastroenterology & hepatology Observational study Female medicine.symptom business Carcinoid syndrome |
| Zdroj: | Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. 36(6) |
| ISSN: | 0975-0711 |
| Popis: | Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare tumors. We report data of 407 GEP-NET cases from a neuroendocrine tumor (NET) registry in India. The AP-NET registry is an open-label, multicenter, longitudinal observational registry of patients with GEP-NETs in which six tertiary care oncology centers contributed data. Data was prospectively entered in a dedicated computerized database and was reviewed retrospectively. The patients were divided into three cohorts—those diagnosed from 2001 to 2005, from 2006 to 2010, and from 2011 to 2016. Of the 407 cases registered, 37 were in Cohort I, 136 in Cohort II, and 234 in Cohort III. Majority were symptomatic with only 98 patients (24.0%) asymptomatic. The most common presentation of non-functional tumors was abdominal pain (42.4%), while functional tumors presented most commonly with carcinoid syndrome. Use of DOTA-PET, introduced in 2011, has increased evaluation in 33.3% patients in Cohort III. The most common primary site was pancreas in all three cohorts. Male preponderance (58.3%) was seen. Histopathological grading was obtained in 230 (56.5%) patients—118 (29%) Grade I, 74 (18.2%) Grade II, and 36 (8.8%) Grade III NET. This report highlights changing trends in the diagnosis and reporting of NETs over the last 15 years. |
| Databáze: | OpenAIRE |
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