Suboptimal declines and delays in early breast cancer treatment after COVID-19 quarantine restrictions in China: A national survey of 8397 patients in the first quarter of 2020
| Autor: | Jishang Chen, Xiaojia Wang, Jianbin Li, Gang Wu, Shengrong Sun, Cuizhi Geng, Quchang Ouyang, Shijun Peng, Haidong Zhao, Geng Wang, Feng Jin, Haiqing Zhang, Haibo Wang, Yin-Hua Liu, Y Liu, Jianyun Nie, Xingrui Li, Feng Yao, Zhenzhen Liu, Jing Cheng, Yiding Chen, Jiayi Chen, Gang Sun, Peifen Fu, Ying Lin, Qianjun Chen, Yongmei Yin, Jingjie Zhang, Zefei Jiang, Xiangshun Kong |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) 01 natural sciences law.invention 03 medical and health sciences 0302 clinical medicine Breast cancer law Quarantine Medicine Treatment decline 030212 general & internal medicine 0101 mathematics China Delay lcsh:R5-920 business.industry Regional disparity 010102 general mathematics Early breast cancer Cancer Outbreak COVID-19 General Medicine medicine.disease Quarter (United States coin) Quarantine restrictions business lcsh:Medicine (General) Cohort study Research Paper |
| Zdroj: | EClinicalMedicine EClinicalMedicine, Vol 26, Iss, Pp 100503-(2020) |
| ISSN: | 2589-5370 |
| DOI: | 10.1016/j.eclinm.2020.100503 |
| Popis: | Background: Cancer patients had been profoundly affected by the outbreak of COVID-19 especially after quarantine restrictions in China We aimed to explore the treatment changes and delays of early breast cancer (EBC) during the first quarter of 2020 Methods: We did this retrospective, multicentre, cohort study at 97 cancer centres in China EBC patients who received treatment regardless of preoperative therapy, surgery or postoperative therapy during first quarter of 2020 were included Findings: 8397 patients were eligible with a median age of 50 (IQR 43–56) 0·2% (15/8397) of EBC patients were confirmed as COVID-19 infection Only 5·2% of breast cancer diagnosis occurred after quarantine in Hubei compared with 15·3% in other provinces (OR= 0·30, 95%CI 0·24–0·38) postoperative endocrine therapy were least affected compared with different regions after quarantine (OR=0·37 [95%CI 0·19–0·73]) The proportion of surgery decreased from 16·4% in December last year to 2·6% in February in Hubei Compared with intervals from diagnosis to treatment before quarantine restrictions, the average time increased with significance from 3·5 to 7·7 days in Hubei and 5·7 to 7·7 days in other provinces (p< 0·001) There were also 18·5 and 7·2 days delay in Hubei and other provinces respectively when calculating interval from surgery to postoperative therapy Interpretation: EBC from high risk regions had a comparative rate of COVID-19 infection After implementation of COVID-19 quarantine restrictions, fewer diagnosis and surgery with significant delays were seen when compared with treatment before Funding: Beijing Medical Award Foundation (YJ0120) |
| Databáze: | OpenAIRE |
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