Experimental diabetes reduces circulating 1,25-dihydroxyvitamin D in the rat
| Autor: | Harold P. Schedl, Mark R. Haussler, Toni A. McCain, Louis E. Schneider |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Vitamin
Male medicine.medical_specialty medicine.medical_treatment chemistry.chemical_element Calcium Streptozocin chemistry.chemical_compound Diabetes mellitus Internal medicine Alloxan polycyclic compounds medicine Diabetes Mellitus Animals Insulin Calcium metabolism Multidisciplinary Catabolism Hydroxycholecalciferols medicine.disease Streptozotocin Rats Endocrinology chemistry Dihydroxycholecalciferols medicine.drug |
| Zdroj: | Science (New York, N.Y.). 196(4297) |
| ISSN: | 0036-8075 |
| Popis: | Duodenal calcium absorption and a vitamin D-dependent duodenal calcium-binding protein are depressed in rats with alloxan- or streptozotocin-induced diabetes. To test for possible abnormal vitamin D metabolism in diabetes we measured serum concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in control, streptozotocin diabetic, and insulin-treated diabetic rats. The serum concentration of 1,25-dihydroxyvitamin D was depressed in untreated diabetic rats to one-eighth of the level in controls and was restored to control levels by insulin treatment. The serum concentration of 25-hydroxyvitamin D was the same in all three groups. Hence, effects of diabetes on duodenal calcium transport can be explained by reduced concentrations of 1,25-dihydroxyvitamin D resulting either from failure of renal 1alpha-hydroxylation of 25-hydroxyvitamin D or increased catabolism of 1,25-dihydroxyvitamin D. |
| Databáze: | OpenAIRE |
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