Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase

Autor:	Sara Forrester, Alan P. Kozikowski, Debbie C. Mulhearn, Michael E. Johnson, Sipak Joyasawal, Scott D. Pegan, Andrew D. Mesecar, Suresh K. Tipparaju
Rok vydání:	2008
Předmět:	Models Molecular Stereochemistry Pyridones Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Reductase Crystallography X-Ray Biochemistry Article Structure-Activity Relationship Drug Discovery Structure–activity relationship Molecular Biology Antibacterial agent chemistry.chemical_classification Bacillaceae biology Molecular Structure Chemistry Organic Chemistry Stereoisomerism biology.organism_classification Bacillales Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) Bacillus anthracis Anti-Bacterial Agents Molecular Weight Enzyme Enzyme inhibitor Drug Design biology.protein Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 18(12)
ISSN:	1464-3405
Popis:	Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fadef7dfda7d0abcd1d1f8890f1219 https://pubmed.ncbi.nlm.nih.gov/18499454 Zobrazit plný text záznamu Full Text from ScienceDirect