Synthesis and biophysical studies of short oligodeoxynudeotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynudeotide synthesis

Autor:	J. Gunning, T.P. Patel, S.D. Cutbush, J. John Mann, T.A. Millican, M.A. Chauncey, M.A.W. Eaton, Stephen Neidle, G.A. Mock
Rok vydání:	1984
Předmět:	Deoxyribose Oligonucleotide Oligonucleotides Nucleic Acid Hybridization Biology Combinatorial chemistry Structure-Activity Relationship Nucleic acid thermodynamics Oligodeoxyribonucleotides Biochemistry Genetic Code Duplex (building) Genetics Structure–activity relationship
Zdroj:	Nucleic Acids Research. 12:7435-7453
ISSN:	1362-4962 0305-1048
Popis:	The syntheses of 1,2-dideoxy-D-ribofuranose and 1,2-dideoxy-1-phenyl-beta-D-ribofuranose are described. Oligodeoxynucleotides containing these analogues have been synthesised and hybridized to their complementary strands. Hypochromicity studies have shown that these duplices are less stable than either the totally complementary duplex or those containing A.C and G.T mismatches.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f9af94338a6790b46f7f26b65e143b https://doi.org/10.1093/nar/12.19.7435 Zobrazit plný text záznamu