Monitoring the effect of substitution therapy in patients with exocrine pancreatic insufficiency
| Autor: | Pedersen Nt, B. Bang Jørgensen, H. Worning |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatic disease Malabsorption Duodenum Oleic Acids Tritium Gastroenterology Excretion Feces Oral administration Internal medicine medicine Humans Carbon Radioisotopes Exocrine pancreatic insufficiency Radionuclide Imaging Aged Monitoring Physiologic business.industry digestive oral and skin physiology Middle Aged medicine.disease Lipid Metabolism medicine.anatomical_structure Endocrinology Pancreatitis Chronic Disease Pancreatin lipids (amino acids peptides and proteins) Exocrine Pancreatic Insufficiency Female Pancreas Digestion business Triolein Oleic Acid |
| Zdroj: | Scandinavian journal of gastroenterology. 26(3) |
| ISSN: | 0036-5521 |
| Popis: | Twenty-three outpatients with chronic pancreatitis and severe exocrine insufficiency were studied for the purpose of comparing the effect of Pancrease, Pankreon, and Pankreatin by estimation of duodenal enzyme activity, the faecal fat excretion, and the faecal 14C-triolein-3H-oleic acid test and, at the same time, to evaluate these tests when monitoring outpatients. The three preparations did not disclose any significant difference in treating steatorrhoea. Pankreatin increased the meal-stimulated duodenal enzyme activity (p less than 0.01) and caused reduction in the faecal fat excretion (p less than 0.05), whereas no change in these variables were observed with Pankreon or Pancrease. The faecal 14C-triolein-3H-oleic acid test showed significant improvement in the 14C-triolein digestion with all three preparations (p less than 0.01). The faecal 14C-triolein-3H-oleic acid test was the most reliable when monitoring outpatients. |
| Databáze: | OpenAIRE |
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