Possible Duplication of Haemoglobin α-Chain Locus in the Irus Macaque
| Autor: | N. A. Barnicot, Patricia T. Wade, E. R. Huehns |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Genetics
Multidisciplinary biology Locus (genetics) Haplorhini Blood Protein Electrophoresis Genetic code Irus biology.organism_classification Biological Evolution Macaque Hemoglobins Genetic Code biology.animal Gene duplication Chromatography Gel Animals Allele Peptides Molecular Biology Gene Alleles Alpha chain |
| Zdroj: | Nature. 215:1485-1487 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/2151485a0 |
| Popis: | THE irus macaque (Macaca irus) is polymorphic for a minor haemoglobin component which resembles human Hb-A2 in electrophoretic mobility and concentration but differs from it in having a common β-chain with the normal major component, Hb-Ami (ref. 1). Two major haemoglobin variants Hb-Pmi and Hb-Qmi are also frequent in this species and these also differ from Hb-Ami in their α-chains. Some animals carry three haemoglobins, for example Hb-Pmi (αPmi2βAmi2), Hb-Ami (αAmi2βAmi2) and the minor component (αXmi2βAmi2), and therefore have three types of α-chain (αAmi, αPmi and αXmi). Hb-Pmi and Hb-Ami are probably deteimined by allelic genes. It was therefore suggested1 that the minor component arose by duplication of the α-locus in a manner analogous to the proposed origin of Hb-A2 by a β-locus duplication2. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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